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The study noted that there was a statistically significant increase in estradiol levels in patients on clomiphene citrate that was not observed with enclomiphene citrate

PLoS Pathog 7(9): e1002250

doi: 10.1007/s00425-009-1095-z 46 OztetikE

Int J Endocrinol

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This short half-life significantly impacts the efficiency of labeling after injection into a patients body, thereby limiting their clinical applications